Head to Head
| Ghana FA Cup | 2021/06/20 15:00 | Karela United FC v Medeama SC | L | 1-2 |
| Ghana Premier League | 2021/06/05 15:00 | Medeama SC v Karela United FC | L | 1-0 |
| Ghana Premier League | 2021/01/31 15:00 | Karela United FC v Medeama SC | W | 2-0 |
| Ghana FA Cup | 2020/02/23 15:00 | Karela United FC v Medeama SC | L | 0-1 |
| Ghana Premier League | 2020/02/09 15:00 | Karela United FC v Medeama SC | D | 1-1 |
| World Club Friendlies | 2018/10/07 15:59 | Karela United FC v Medeama SC | L | 0-2 |
| Ghana Premier League | 2018/03/18 15:00 | Medeama SC v Karela United FC | L | 1-0 |
| World Club Friendlies | 2018/01/14 15:13 | Karela United FC v Medeama SC | D | 0-0 |
Home History
| Ghana Premier League | 2021/10/31 15:00 | Karela United FC v Aduana Stars | D | 1-1 |
| Ghana Premier League | 2021/07/18 15:00 | Aduana Stars v Karela United FC | L | 2-1 |
| Ghana Premier League | 2021/07/11 15:00 | Karela United FC v WAFA | L | 0-2 |
| Ghana Premier League | 2021/07/04 15:00 | Liberty Professionals v Karela United FC | L | 3-2 |
| Ghana Premier League | 2021/06/28 15:00 | Karela United FC v Ebusua Dwarfs | L | 1-4 |
| Ghana Premier League | 2021/06/23 15:00 | Asante Kotoko v Karela United FC | L | 2-1 |
| Ghana FA Cup | 2021/06/20 15:00 | Karela United FC v Medeama SC | L | 1-2 |
| Ghana Premier League | 2021/06/13 15:00 | Karela United FC v Legon Cities FC | W | 2-0 |
Away History
| Ghana Premier League | 2021/10/31 15:00 | Bechem FC v Medeama SC | L | 4-0 |
| Ghana FA Cup | 2021/08/01 18:00 | Hearts of Oak v Medeama SC | L | 3-0 |
| Ghana FA Cup | 2021/07/25 15:00 | Medeama SC v Attram De Visser | W | 3-2 |
| Ghana Premier League | 2021/07/18 15:00 | Medeama SC v Berekum Chelsea | W | 1-0 |
| Ghana Premier League | 2021/07/11 15:00 | Eleven Wonders v Medeama SC | L | 3-1 |
| Ghana FA Cup | 2021/07/07 15:00 | Medeama SC v Great Olympics | W | 5-3 |
| Ghana Premier League | 2021/07/04 15:00 | Medeama SC v Elmina Sharks | W | 3-2 |
| Ghana Premier League | 2021/06/27 15:00 | Bechem FC v Medeama SC | D | 0-0 |