[12] Santos Laguna 1-1 Tigres UANL [13] 2021-09-18 10:06
Stadium: Estadio TSM Corona Round: 1
Referee: Adonai Escobedo Gonzalez Home Manager: Pedro Caixinha Away Manager: Miguel Herrera
Head to Head
| Mexico Liga MX | 2021/08/08 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/01/18 01:06 | Santos Laguna v Tigres UANL | W | 2-0 |
| Mexico Liga MX | 2020/09/13 00:00 | Tigres UANL v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2020/02/17 00:45 | Santos Laguna v Tigres UANL | W | 2-1 |
| Mexico Liga MX | 2019/10/06 00:00 | Tigres UANL v Santos Laguna | L | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | W | 3-2 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2019/02/03 01:00 | Tigres UANL v Santos Laguna | L | 2-1 |
Home History
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/08/29 23:00 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexico Liga MX | 2021/08/22 00:00 | Leon v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/08/19 00:00 | Santos Laguna v Atlas | D | 1-1 |
| Mexico Liga MX | 2021/08/16 00:06 | Santos Laguna v Chivas Guadalajara | D | 0-0 |
| Leagues Cup | 2021/08/12 23:00 | Orlando City SC v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2021/08/08 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |
Away History
| Mexico Liga MX | 2021/09/12 00:00 | Tigres UANL v Leon | D | 2-2 |
| Mexico Liga MX | 2021/08/29 00:00 | Tigres UANL v Atlas | D | 1-1 |
| Mexico Liga MX | 2021/08/21 02:00 | Mazatlan FC v Tigres UANL | W | 0-3 |
| Mexico Liga MX | 2021/08/18 00:00 | Tigres UANL v Queretaro | W | 3-0 |
| Mexico Liga MX | 2021/08/14 00:00 | Puebla v Tigres UANL | D | 1-1 |
| Leagues Cup | 2021/08/11 02:00 | Seattle Sounders v Tigres UANL | L | 3-0 |
| Mexico Liga MX | 2021/08/08 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/08/01 17:00 | Toluca v Tigres UANL | L | 3-1 |