Head to Head
| NCAAF | 2014/09/06 23:00 | Louisville v Murray State | L | 66-21 |
| NCAAF | 2011/09/01 12:00 | Louisville v Murray State | L | 21-9 |
| NCAAF | 2007/08/30 12:00 | Louisville v Murray State | L | 73-10 |
Home History
| NCAAF | 2016/09/03 19:30 | Illinois v Murray State | L | 52-3 |
| NCAAF | 2015/09/19 23:00 | Western Michigan v Murray State | L | 52-20 |
| NCAAF | 2015/09/12 19:30 | Northern Illinois v Murray State | L | 57-26 |
| NCAAF | 2014/09/20 23:00 | Western Michigan v Murray State | L | 45-14 |
| NCAAF | 2014/09/06 23:00 | Louisville v Murray State | L | 66-21 |
| NCAAF | 2012/09/01 12:00 | Florida State v Murray State | L | 69-3 |
| NCAAF | 2011/09/01 12:00 | Louisville v Murray State | L | 21-9 |
| NCAAF | 2010/09/02 12:00 | Kent State v Murray State | L | 41-10 |
Away History
| NCAAF | 2016/12/31 16:00 | LSU v Louisville | L | 29-9 |
| NCAAF | 2016/11/26 17:00 | Kentucky v Louisville | L | 41-38 |
| NCAAF | 2016/11/18 01:00 | Louisville v Houston | L | 10-36 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | W | 12-44 |
| NCAAF | 2016/11/05 16:00 | Louisville v Boston College | W | 52-7 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virginia | W | 32-25 |
| NCAAF | 2016/10/22 16:00 | NC State v Louisville | W | 13-54 |
| NCAAF | 2016/10/14 23:00 | Duke v Louisville | W | 14-24 |