Head to Head
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | L | 4-0 |
| Mexico Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlan FC | W | 2-4 |
| Mexico Liga MX | 2016/05/01 01:30 | Mazatlan FC v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2015/11/07 03:30 | Santos Laguna v Mazatlan FC | W | 2-3 |
| Mexico Liga MX | 2015/04/04 01:30 | Mazatlan FC v Santos Laguna | L | 0-1 |
| Mexico Liga MX | 2014/10/05 01:00 | Santos Laguna v Mazatlan FC | D | 2-2 |
Home History
| Mexico Liga MX | 2021/09/19 02:00 | Mazatlan FC v Unam Pumas | D | 2-2 |
| Mexico Liga MX | 2021/09/12 02:00 | Club America v Mazatlan FC | L | 2-0 |
| Mexico Liga MX | 2021/08/28 00:00 | Mazatlan FC v Atletico San Luis | D | 2-2 |
| Mexico Liga MX | 2021/08/21 02:00 | Mazatlan FC v Tigres UANL | L | 0-3 |
| Mexico Liga MX | 2021/08/17 22:00 | Toluca v Mazatlan FC | D | 2-2 |
| Mexico Liga MX | 2021/08/15 00:00 | Leon v Mazatlan FC | L | 3-0 |
| Mexico Liga MX | 2021/08/07 00:00 | Mazatlan FC v Monterrey | D | 1-1 |
| Mexico Liga MX | 2021/07/31 00:00 | Mazatlan FC v Pachuca | W | 2-1 |
Away History
| Mexico Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/08/29 23:00 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexico Liga MX | 2021/08/22 00:00 | Leon v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/08/19 00:00 | Santos Laguna v Atlas | D | 1-1 |
| Mexico Liga MX | 2021/08/16 00:06 | Santos Laguna v Chivas Guadalajara | D | 0-0 |
| Leagues Cup | 2021/08/12 23:00 | Orlando City SC v Santos Laguna | W | 0-1 |