[9] NY Islanders 3-5 BUF Sabres [5] 2022-02-26 20:30
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-6 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | W | 1-4 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
Home History
| NHL | 2022/02/25 03:30 | NY Islanders v SJ Sharks | L | 3-4 |
| NHL | 2022/02/23 03:00 | NY Islanders v SEA Kraken | W | 5-2 |
| NHL | 2022/02/20 19:00 | MTL Canadiens v NY Islanders | L | 3-2 |
| NHL | 2022/02/18 00:30 | BOS Bruins v NY Islanders | W | 1-4 |
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-6 |
| NHL | 2022/02/13 03:00 | NY Islanders v CGY Flames | L | 2-5 |
| NHL | 2022/02/12 02:00 | NY Islanders v EDM Oilers | L | 1-3 |
| NHL | 2022/02/10 03:30 | NY Islanders v VAN Canucks | W | 6-3 |
Away History
| NHL | 2022/02/26 01:00 | BUF Sabres v STL Blues | L | 3-5 |
| NHL | 2022/02/24 00:30 | BUF Sabres v MTL Canadiens | L | 0-4 |
| NHL | 2022/02/20 23:00 | BUF Sabres v CLB Blue Jackets | L | 3-7 |
| NHL | 2022/02/19 18:00 | COL Avalanche v BUF Sabres | L | 5-3 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-6 |
| NHL | 2022/02/13 17:30 | BUF Sabres v MTL Canadiens | W | 5-3 |
| NHL | 2022/02/11 00:00 | CLB Blue Jackets v BUF Sabres | L | 4-3 |