[22] John Isner 6-7,4-6 Hugo Gaston [68] 2022-03-10 18:05
Stadium: Butch Buchholz Round: 24 Ground: Hardcourt outdoor
Home History
| ATP Acapulco | 2022/02/24 00:00 | Cameron Norrie v John Isner | 6-7,6-3,6-4 |
| ATP Acapulco | 2022/02/22 00:00 | Fernando Verdasco v John Isner | 5-7,7-6,6-7 |
| ATP Dallas | 2022/02/12 22:00 | John Isner v Reilly Opelka | 6-7,6-7 |
| ATP Dallas | 2022/02/12 01:00 | Vasek Pospisil v John Isner | 4-6,4-6 |
| ATP Dallas | 2022/02/10 01:00 | Kevin Anderson v John Isner | 6-7,7-6,6-7 |
| Australian Open | 2022/01/18 03:15 | Maxime Cressy v John Isner | 7-6,7-5,6-7,6-7,6-4 |
| ATP Adelaide 2 | 2022/01/12 04:30 | Thanasi Kokkinakis v John Isner | 6-7,7-6,7-6 |
| ATP Cup | 2022/01/05 23:00 | Daniel Evans v John Isner | 6-4,7-6 |
Away History
| ATP Marseille | 2022/02/17 18:00 | Stefanos Tsitsipas v Hugo Gaston | 6-3,7-6 |
| ATP Marseille | 2022/02/15 19:30 | Hugo Gaston v Corentin Moutet | 6-4,6-4 |
| ATP Rotterdam | 2022/02/09 12:55 | Hugo Gaston v Soonwoo Kwon | 3-6,3-6 |
| ATP Rotterdam | 2022/02/06 12:25 | Hugo Gaston v Bernabe Zapata Miralles | 5-7,7-5,2-6 |
| ATP Rotterdam | 2022/02/05 15:50 | Hugo Gaston v Robin Haase | 6-1,7-6 |
| ATP Montpellier | 2022/02/01 18:30 | Hugo Gaston v Soonwoo Kwon | 2-6,1-6 |
| Australian Open | 2022/01/18 00:00 | Christopher O'Connell v Hugo Gaston | 7-6,6-0,4-6,6-1 |
| ATP Sydney | 2022/01/10 03:40 | Hugo Gaston v Lorenzo Sonego | 6-3,3-6,5-7 |