[101] Notre Dame 45-32 North Carolina [10] 2022-07-31 09:30
Stadium: Kenan Stadium Round: 1
Home Manager: Marcus Freeman Away Manager: Mack Brown
Head to Head
| NCAAF | 2021/10/30 23:30 | North Carolina v Notre Dame | W | 34-44 |
| NCAAF | 2020/11/27 20:30 | Notre Dame v North Carolina | W | 31-17 |
| NCAAF | 2017/10/07 19:30 | Notre Dame v North Carolina | W | 33-10 |
| NCAAF | 2014/10/11 19:30 | Notre Dame v North Carolina | W | 50-43 |
| NCAAF | 2008/10/11 12:00 | North Carolina v Notre Dame | L | 29-24 |
| NCAAF | 2006/11/04 12:00 | Notre Dame v North Carolina | W | 45-26 |
Home History
| NCAAF Bowl Games | 2022/01/01 18:00 | Oklahoma State v Notre Dame | L | 37-35 |
| NCAAF | 2021/11/28 01:00 | Notre Dame v Stanford | W | 45-14 |
| NCAAF | 2021/11/20 19:30 | Georgia Tech v Notre Dame | W | 0-55 |
| NCAAF | 2021/11/14 00:30 | Notre Dame v Virginia | W | 28-3 |
| NCAAF | 2021/11/06 19:30 | Navy v Notre Dame | W | 6-34 |
| NCAAF | 2021/10/30 23:30 | North Carolina v Notre Dame | W | 34-44 |
| NCAAF | 2021/10/23 23:30 | USC v Notre Dame | W | 16-31 |
| NCAAF | 2021/10/09 23:30 | Notre Dame v Virginia Tech | W | 32-29 |
Away History
| NCAAF Bowl Games | 2021/12/30 16:30 | South Carolina v North Carolina | L | 38-21 |
| NCAAF | 2021/11/27 00:00 | North Carolina v NC State | L | 30-34 |
| NCAAF | 2021/11/20 17:00 | Wofford v North Carolina | W | 14-34 |
| NCAAF | 2021/11/12 00:30 | North Carolina v Pittsburgh | L | 23-30 |
| NCAAF | 2021/11/06 16:00 | Wake Forest v North Carolina | W | 55-58 |
| NCAAF | 2021/10/30 23:30 | North Carolina v Notre Dame | L | 34-44 |
| NCAAF | 2021/10/16 19:30 | Miami Florida v North Carolina | W | 42-45 |
| NCAAF | 2021/10/09 19:30 | Florida State v North Carolina | L | 35-25 |