[14] Guayaquil City 4-1 Mushuc Runa [13] 2022-05-28 00:00
Stadium: Estadio Christian Benitez Betancourt Round: 11
Referee: Alex Fabricio Cajas Torres Home Manager: Pool Gavilanez Away Manager: Geovanny Cumbicus
Head to Head
| Ecuador LigaPro Serie A | 2022/04/30 20:00 | Mushuc Runa v Guayaquil City | L | 2-0 |
| Ecuador LigaPro Serie A | 2021/11/21 20:30 | Mushuc Runa v Guayaquil City | L | 1-0 |
| Ecuador LigaPro Serie A | 2021/05/29 21:30 | Guayaquil City v Mushuc Runa | D | 0-0 |
| Ecuador LigaPro Serie A | 2020/11/14 18:00 | Guayaquil City v Mushuc Runa | W | 3-2 |
| Ecuador LigaPro Serie A | 2020/09/26 19:45 | Mushuc Runa v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2019/08/25 19:45 | Guayaquil City v Mushuc Runa | W | 4-2 |
| Ecuador LigaPro Serie A | 2019/04/06 20:00 | Mushuc Runa v Guayaquil City | L | 3-2 |
| Ecuador LigaPro Serie A | 2016/10/30 17:00 | Mushuc Runa v Guayaquil City | W | 0-2 |
Home History
| Ecuador LigaPro Serie A | 2022/05/22 01:00 | Guayaquil City v LDU Quito | D | 2-2 |
| Ecuador LigaPro Serie A | 2022/05/17 00:00 | Gualaceo SC v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2022/05/11 22:00 | Club 9 de Octubre v Guayaquil City | D | 2-2 |
| Ecuador LigaPro Serie A | 2022/05/09 00:00 | Guayaquil City v Barcelona Guayaquil | L | 1-4 |
| Ecuador LigaPro Serie A | 2022/04/30 20:00 | Mushuc Runa v Guayaquil City | L | 2-0 |
| Ecuador LigaPro Serie A | 2022/04/26 00:00 | Guayaquil City v Cumbaya | W | 4-1 |
| Ecuador LigaPro Serie A | 2022/04/16 22:30 | Guayaquil City v SD Aucas | W | 4-0 |
| Ecuador LigaPro Serie A | 2022/04/10 18:00 | Independiente del Valle v Guayaquil City | D | 0-0 |
Away History
| Ecuador LigaPro Serie A | 2022/05/23 00:00 | Independiente del Valle v Mushuc Runa | W | 0-1 |
| Ecuador LigaPro Serie A | 2022/05/14 19:00 | Mushuc Runa v SD Aucas | D | 1-1 |
| Ecuador LigaPro Serie A | 2022/05/08 01:00 | Emelec v Mushuc Runa | L | 4-0 |
| Ecuador LigaPro Serie A | 2022/04/30 20:00 | Mushuc Runa v Guayaquil City | W | 2-0 |
| Ecuador LigaPro Serie A | 2022/04/24 19:30 | LDU Quito v Mushuc Runa | L | 3-2 |
| Ecuador LigaPro Serie A | 2022/04/21 18:00 | Mushuc Runa v Macara | D | 0-0 |
| Ecuador LigaPro Serie A | 2022/04/16 00:00 | Gualaceo SC v Mushuc Runa | L | 3-2 |
| Ecuador LigaPro Serie A | 2022/04/09 19:30 | Mushuc Runa v Delfin SC | L | 1-2 |