[14] UL Lafayette 24-39 Southern Miss [9] 2022-09-29 15:30
Stadium: M.M. Roberts Stadium Round: 1
Home Manager: Michael Desormeaux Away Manager: Will Hall
Head to Head
| NCAAF | 2016/12/18 02:00 | Southern Mississippi v Lafayette | L | 28-21 |
| NCAAF | 2008/08/30 12:00 | Southern Mississippi v Lafayette | L | 51-21 |
| NCAAF | 2003/11/01 12:00 | Southern Mississippi v Lafayette | L | 48-3 |
| NCAAF | 2001/09/22 12:00 | Lafayette v Southern Mississippi | L | 10-35 |
Home History
| NCAAF | 2022/09/25 00:00 | Lafayette v UL Monroe | L | 17-21 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | L | 0-12 |
| NCAAF | 2022/09/17 23:30 | Lafayette v Rice | L | 21-33 |
| NCAAF | 2022/09/17 19:30 | William & Mary v Lafayette | L | 34-7 |
| NCAAF | 2022/09/10 23:00 | Eastern Michigan v Lafayette | W | 21-49 |
| NCAAF | 2022/09/10 18:00 | Lafayette v Temple | L | 14-30 |
| NCAAF | 2022/09/03 23:00 | SE Louisiana v Lafayette | W | 7-24 |
| NCAAF | 2022/09/03 16:30 | Sacred Heart v Lafayette | W | 0-6 |
Away History
| NCAAF | 2022/09/24 23:00 | Southern Mississippi v Tulane | W | 27-24 |
| NCAAF | 2022/09/17 23:00 | Northwestern State v Southern Mississippi | W | 10-64 |
| NCAAF | 2022/09/10 16:00 | Southern Mississippi v Miami Florida | L | 7-30 |
| NCAAF | 2022/09/03 23:00 | Liberty v Southern Mississippi | L | 29-27 |
| NCAAF | 2021/11/27 20:00 | Florida Intl v Southern Mississippi | W | 17-37 |
| NCAAF | 2021/11/20 01:00 | Southern Mississippi v Louisiana Tech | W | 35-19 |
| NCAAF | 2021/11/13 20:30 | Southern Mississippi v Texas-San Antonio | L | 17-27 |
| NCAAF | 2021/11/06 19:00 | North Texas v Southern Mississippi | L | 38-14 |