[4] East Carolina 25-27 Cincinnati [3] 2022-08-12 19:00
Stadium: Nippert Stadium Round: 1
Home Manager: Mike Houston Away Manager: Luke Fickell
Head to Head
| NCAAF | 2021/11/26 20:30 | Cincinnati v East Carolina | L | 35-13 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2019/11/02 23:00 | Cincinnati v East Carolina | L | 46-43 |
| NCAAF | 2018/11/23 20:30 | East Carolina v Cincinnati | L | 6-56 |
| NCAAF | 2017/11/18 17:00 | Cincinnati v East Carolina | W | 20-48 |
| NCAAF | 2016/10/22 23:00 | East Carolina v Cincinnati | L | 19-31 |
| NCAAF | 2015/11/28 17:00 | East Carolina v Cincinnati | L | 16-19 |
| NCAAF | 2014/11/14 00:00 | Cincinnati v East Carolina | L | 54-46 |
Home History
| NCAAF | 2021/11/26 20:30 | Cincinnati v East Carolina | L | 35-13 |
| NCAAF | 2021/11/20 20:30 | East Carolina v Navy | W | 38-35 |
| NCAAF | 2021/11/13 17:00 | East Carolina v Memphis | W | 30-29 |
| NCAAF | 2021/11/06 19:00 | Temple v East Carolina | W | 3-45 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | W | 14-29 |
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | L | 24-31 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | L | 16-20 |
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
Away History
| NCAAF | 2021/12/31 20:30 | Cincinnati v Alabama | L | 6-27 |
| NCAAF | 2021/12/04 21:00 | Houston v Cincinnati | W | 20-35 |
| NCAAF | 2021/11/26 20:30 | Cincinnati v East Carolina | W | 35-13 |
| NCAAF | 2021/11/20 20:30 | SMU v Cincinnati | W | 14-48 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | W | 45-28 |
| NCAAF | 2021/11/06 19:30 | Tulsa v Cincinnati | W | 20-28 |
| NCAAF | 2021/10/30 16:00 | Cincinnati v Tulane | W | 31-12 |
| NCAAF | 2021/10/23 16:00 | Cincinnati v Navy | W | 27-20 |