[11] Southampton 0-1 Man Utd [14] 2022-05-16 23:30
Stadium: St. Mary's Stadium Round: 4
Referee: Andrew Madley Home Manager: Ralph Hasenhuttl Away Manager: Erik ten Hag
Head to Head
| England Premier League | 2022/02/12 12:30 | Man Utd v Southampton | D | 1-1 |
| England Premier League | 2021/08/22 13:00 | Southampton v Man Utd | D | 1-1 |
| England Premier League | 2021/02/02 20:15 | Man Utd v Southampton | L | 9-0 |
| England Premier League | 2020/11/29 14:00 | Southampton v Man Utd | L | 2-3 |
| England Premier League | 2020/07/13 19:00 | Man Utd v Southampton | D | 2-2 |
| England Premier League | 2019/08/31 11:30 | Southampton v Man Utd | D | 1-1 |
| England Premier League | 2019/03/02 15:00 | Man Utd v Southampton | L | 3-2 |
| England Premier League | 2018/12/01 17:30 | Southampton v Man Utd | D | 2-2 |
Home History
| England Premier League | 2022/05/07 14:00 | Brentford v Southampton | L | 3-0 |
| England Premier League | 2022/04/30 14:00 | Southampton v Crystal Palace | L | 1-2 |
| England Premier League | 2022/04/24 13:00 | Brighton v Southampton | D | 2-2 |
| England Premier League | 2022/04/21 18:45 | Burnley v Southampton | L | 2-0 |
| England Premier League | 2022/04/16 14:00 | Southampton v Arsenal | W | 1-0 |
| England Premier League | 2022/04/09 14:00 | Southampton v Chelsea | L | 0-6 |
| England Premier League | 2022/04/02 14:00 | Leeds v Southampton | D | 1-1 |
| England FA Cup | 2022/03/20 15:00 | Southampton v Man City | L | 1-4 |
Away History
| England Premier League | 2022/05/07 16:30 | Brighton v Man Utd | L | 4-0 |
| England Premier League | 2022/05/02 19:00 | Man Utd v Brentford | W | 3-0 |
| England Premier League | 2022/04/28 18:45 | Man Utd v Chelsea | D | 1-1 |
| England Premier League | 2022/04/23 11:30 | Arsenal v Man Utd | L | 3-1 |
| England Premier League | 2022/04/19 19:00 | Liverpool v Man Utd | L | 4-0 |
| England Premier League | 2022/04/16 14:00 | Man Utd v Norwich | W | 3-2 |
| England Premier League | 2022/04/09 11:30 | Everton v Man Utd | L | 1-0 |
| England Premier League | 2022/04/02 16:30 | Man Utd v Leicester | D | 1-1 |