[6] Leones 1-1 CD Real Santander [7] 2022-04-02 19:00
Stadium: Estadio Metropolitano Ciudad de Itagui Round: 5
Head to Head
| Colombia Primera B | 2022/03/21 18:45 | Real San Andres v Leones | W | 0-4 |
| Colombia Primera B | 2021/08/20 01:00 | Leones v Real San Andres | W | 2-1 |
| Colombia Cup | 2021/04/21 20:15 | Real San Andres v Leones | L | 2-0 |
| Colombia Cup | 2021/04/15 00:40 | Leones v Real San Andres | L | 1-3 |
| Colombia Primera B | 2021/04/09 20:30 | Leones v Real San Andres | W | 2-0 |
| Colombia Primera B | 2020/11/02 20:30 | Real San Andres v Leones | W | 0-3 |
| Colombia Primera B | 2019/10/06 20:30 | Real San Andres v Leones | L | 3-1 |
| Colombia Primera B | 2019/04/28 20:00 | Leones v Real San Andres | W | 3-0 |
Home History
| Colombia Primera B | 2022/03/25 23:05 | Leones v Atletico Cali FC | D | 1-1 |
| Colombia Primera B | 2022/03/21 18:45 | Real San Andres v Leones | W | 0-4 |
| Colombia Primera B | 2022/03/10 20:00 | Leones v Real Cartagena | W | 1-0 |
| Colombia Primera B | 2022/03/07 20:30 | Atletico Huila v Leones | D | 1-1 |
| Colombia Primera B | 2022/02/27 19:00 | Leones v Barranquilla FC | W | 3-1 |
| Colombia Cup | 2022/02/23 20:00 | Leones v Tigres FC | D | 1-1 |
| Colombia Primera B | 2022/02/19 20:00 | Fortaleza CEIF v Leones | W | 1-2 |
| Colombia Primera B | 2022/02/17 01:00 | Boyaca Chico v Leones | L | 1-0 |
Away History
| Colombia Cup | 2022/03/30 20:00 | Union Magdalena v Real San Andres | L | 3-1 |
| Colombia Primera B | 2022/03/26 20:00 | Bogota FC v Real San Andres | L | 2-1 |
| Colombia Primera B | 2022/03/21 18:45 | Real San Andres v Leones | L | 0-4 |
| Colombia Cup | 2022/03/15 19:00 | Real San Andres v Boyaca Chico | W | 2-1 |
| Colombia Primera B | 2022/03/09 23:00 | Atletico Cali FC v Real San Andres | W | 0-1 |
| Colombia Cup | 2022/03/02 23:00 | Boyaca Chico v Real San Andres | W | 0-1 |
| Colombia Primera B | 2022/02/27 20:00 | Real San Andres v Real Cartagena | L | 1-2 |
| Colombia Cup | 2022/02/23 21:00 | Barranquilla FC v Real San Andres | D | 0-0 |