[21] PIT Penguins 3-6 BUF Sabres [8] 2022-07-09 17:30
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Sullivan
Head to Head
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | L | 3-4 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | W | 2-3 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | L | 2-1 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | W | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | W | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | L | 2-4 |
Home History
| NHL | 2022/05/15 23:00 | PIT Penguins v NY Rangers | L | 3-4 |
| NHL | 2022/05/13 23:00 | NY Rangers v PIT Penguins | L | 5-3 |
| NHL | 2022/05/11 23:00 | PIT Penguins v NY Rangers | L | 3-5 |
| NHL | 2022/05/09 23:00 | NY Rangers v PIT Penguins | W | 2-7 |
| NHL | 2022/05/07 23:00 | NY Rangers v PIT Penguins | W | 4-7 |
| NHL | 2022/05/05 23:00 | PIT Penguins v NY Rangers | L | 2-5 |
| NHL | 2022/05/03 23:00 | PIT Penguins v NY Rangers | W | 4-3 |
| NHL | 2022/04/29 23:00 | CLB Blue Jackets v PIT Penguins | W | 3-5 |
Away History
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |