[2] BOS Bruins 3-1 BUF Sabres [21] 2022-09-28 04:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Jim Montgomery
Head to Head
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | W | 0-5 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | W | 3-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | W | 5-1 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | W | 4-1 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | W | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | W | 2-5 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | L | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | W | 5-1 |
Home History
| NHL Pre-Season | 2022/09/27 23:00 | NY Rangers v BOS Bruins | W | 2-3 |
| NHL Pre-Season | 2022/09/24 23:00 | BOS Bruins v PHI Flyers | L | 1-2 |
| NHL | 2022/05/14 20:30 | BOS Bruins v CAR Hurricanes | L | 2-3 |
| NHL | 2022/05/12 23:00 | CAR Hurricanes v BOS Bruins | W | 2-5 |
| NHL | 2022/05/10 23:00 | BOS Bruins v CAR Hurricanes | L | 1-5 |
| NHL | 2022/05/08 16:30 | CAR Hurricanes v BOS Bruins | W | 2-5 |
| NHL | 2022/05/06 23:00 | CAR Hurricanes v BOS Bruins | W | 2-4 |
| NHL | 2022/05/04 23:00 | BOS Bruins v CAR Hurricanes | L | 2-5 |
Away History
| NHL Pre-Season | 2022/09/27 23:00 | PHI Flyers v BUF Sabres | W | 1-2 |
| NHL Pre-Season | 2022/09/25 18:00 | BUF Sabres v WAS Capitals | W | 4-3 |
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |