[26] BUF Sabres 1-4 OTT Senators [30] 2022-07-28 08:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | W | 2-5 |
Home History
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
Away History
| NHL | 2022/04/29 23:00 | OTT Senators v PHI Flyers | W | 4-2 |
| NHL | 2022/04/28 23:00 | FLA Panthers v OTT Senators | L | 4-0 |
| NHL | 2022/04/26 23:00 | NJ Devils v OTT Senators | W | 4-5 |
| NHL | 2022/04/23 23:00 | MTL Canadiens v OTT Senators | W | 4-6 |
| NHL | 2022/04/22 23:00 | OTT Senators v CLB Blue Jackets | W | 2-1 |
| NHL | 2022/04/20 02:00 | OTT Senators v VAN Canucks | W | 4-3 |
| NHL | 2022/04/19 02:00 | OTT Senators v SEA Kraken | L | 2-4 |
| NHL | 2022/04/16 23:00 | TOR Maple Leafs v OTT Senators | L | 5-4 |