Butler 17-45 South Dakota State 2022-05-31 19:00
Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Mike Uremovich
Home History
| NCAAF | 2021/11/20 17:00 | Butler v Marist | W | 28-21 |
| NCAAF | 2021/11/13 17:00 | Valparaiso v Butler | L | 47-3 |
| NCAAF | 2021/10/30 17:00 | Butler v Dayton | L | 31-38 |
| NCAAF | 2021/10/23 17:00 | Davidson Wildcats v Butler | L | 49-35 |
| NCAAF | 2021/10/16 19:00 | Butler v Morehead State | L | 8-31 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler | L | 52-21 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | L | 6-3 |
| NCAAF | 2021/09/25 17:00 | Butler v St. Thomas (MN) | L | 0-36 |
Away History
| NCAAF | 2021/12/18 19:00 | South Dakota State v Montana State | L | 17-31 |
| NCAAF | 2021/12/11 19:00 | South Dakota State v Villanova | W | 35-21 |
| NCAAF | 2021/12/05 02:00 | South Dakota State v CS Sacramento | W | 24-19 |
| NCAAF | 2021/11/27 20:00 | UC Davis v South Dakota State | W | 24-56 |
| NCAAF | 2021/11/20 20:00 | North Dakota v South Dakota State | W | 21-24 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | L | 20-23 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |