Western Illinois 13-20 Illinois State 2022-07-16 01:00
Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Myers Hendrickson
Head to Head
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | L | 18-26 |
| NCAAF | 2019/10/19 18:00 | Illinois State v Western Illinois | L | 28-14 |
| NCAAF | 2018/10/06 19:00 | Western Illinois v Illinois State | L | 16-33 |
| NCAAF | 2017/11/04 17:00 | Illinois State v Western Illinois | W | 14-31 |
| NCAAF | 2015/12/05 19:00 | Illinois State v Western Illinois | L | 36-19 |
Home History
| NCAAF | 2021/11/20 19:00 | Western Illinois v Northern Iowa | L | 3-41 |
| NCAAF | 2021/11/06 17:00 | South Dakota v Western Illinois | L | 42-21 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | L | 10-34 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | L | 41-17 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | L | 27-37 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | L | 31-30 |
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | W | 38-35 |
Away History
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | L | 15-10 |
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | L | 7-14 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | L | 31-38 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | L | 41-20 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |