Western Illinois 13-20 Illinois State 2022-10-19 11:00
Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Myers Hendrickson
Head to Head
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | L | 18-26 |
| NCAAF | 2019/10/19 18:00 | Illinois State v Western Illinois | L | 28-14 |
| NCAAF | 2018/10/06 19:00 | Western Illinois v Illinois State | L | 16-33 |
| NCAAF | 2017/11/04 17:00 | Illinois State v Western Illinois | W | 14-31 |
| NCAAF | 2015/12/05 19:00 | Illinois State v Western Illinois | L | 36-19 |