[1] Ohio State 21-7 Northwestern [4] 2022-08-21 00:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Ryan Day
Head to Head
| NCAAF | 2020/12/19 17:00 | Northwestern v Ohio State | W | 10-22 |
| NCAAF | 2019/10/19 00:30 | Ohio State v Northwestern | W | 52-3 |
| NCAAF | 2018/12/02 01:00 | Northwestern v Ohio State | W | 24-45 |
| NCAAF | 2016/10/29 19:30 | Northwestern v Ohio State | W | 20-24 |
| NCAAF | 2008/11/08 12:00 | Northwestern v Ohio State | W | 10-45 |
| NCAAF | 2007/09/22 12:00 | Ohio State v Northwestern | W | 58-7 |
| NCAAF | 2006/11/11 12:00 | Northwestern v Ohio State | W | 10-54 |
| NCAAF | 2005/11/12 12:00 | Ohio State v Northwestern | W | 48-7 |
Home History
| NCAAF Bowl Games | 2022/01/01 22:00 | Utah v Ohio State | W | 45-48 |
| NCAAF | 2021/11/27 17:00 | Ohio State v Michigan | L | 27-42 |
| NCAAF | 2021/11/20 17:00 | Michigan State v Ohio State | W | 7-56 |
| NCAAF | 2021/11/13 20:30 | Purdue v Ohio State | W | 31-59 |
| NCAAF | 2021/11/06 16:00 | Ohio State v Nebraska | W | 26-17 |
| NCAAF | 2021/10/30 23:30 | Penn State v Ohio State | W | 24-33 |
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | W | 54-7 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | W | 17-66 |
Away History
| NCAAF | 2021/11/27 20:30 | Northwestern v Illinois | L | 14-47 |
| NCAAF | 2021/11/20 17:00 | Purdue v Northwestern | L | 32-14 |
| NCAAF | 2021/11/13 17:00 | Northwestern v Wisconsin | L | 7-35 |
| NCAAF | 2021/11/06 23:00 | Iowa v Northwestern | L | 17-12 |
| NCAAF | 2021/10/30 19:30 | Minnesota v Northwestern | L | 41-14 |
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | L | 7-33 |
| NCAAF | 2021/10/16 16:00 | Rutgers v Northwestern | W | 7-21 |
| NCAAF | 2021/10/02 23:30 | Northwestern v Nebraska | L | 7-56 |