[14] Louisville 34-17 Sakuramoto/Takahata [13] 2022-05-31 16:00
Stadium: Scott Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Tony Elliott
Head to Head
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2019/10/26 19:30 | Virginia v Louisville | W | 21-28 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virginia | L | 3-27 |
| NCAAF | 2017/11/11 20:30 | Virginia v Louisville | W | 21-38 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virginia | W | 32-25 |
| NCAAF | 2015/11/14 17:30 | Louisville v Virginia | W | 38-31 |
| NCAAF | 2014/09/13 16:30 | Virginia v Louisville | L | 23-21 |
Home History
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
Away History
| NCAAF | 2021/11/27 20:45 | Virginia Tech v Virginia | L | 29-24 |
| NCAAF | 2021/11/20 20:30 | Virginia v Pittsburgh | L | 38-48 |
| NCAAF | 2021/11/14 00:30 | Notre Dame v Virginia | L | 28-3 |
| NCAAF | 2021/10/31 02:15 | Virginia v BYU | L | 49-66 |
| NCAAF | 2021/10/23 23:30 | Georgia Tech v Virginia | W | 40-48 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | W | 0-48 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | W | 34-33 |
| NCAAF | 2021/09/30 23:30 | Virginia v Miami Florida | W | 30-28 |