[1] James Madison 10-34 Louisville [14] 2022-06-15 05:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Curt Cignetti Away Manager: Scott Satterfield
Home History
| NCAAF | 2021/12/18 02:15 | James Madison v North Dakota State | L | 14-20 |
| NCAAF | 2021/12/11 00:00 | Montana v James Madison | W | 6-28 |
| NCAAF | 2021/12/04 19:00 | SE Louisiana v James Madison | W | 20-59 |
| NCAAF | 2021/11/20 19:00 | Towson v James Madison | W | 10-56 |
| NCAAF | 2021/11/13 20:30 | James Madison v William & Mary | W | 32-22 |
| NCAAF | 2021/11/06 19:30 | Campbell v James Madison | W | 14-51 |
| NCAAF | 2021/10/30 18:00 | Elon v James Madison | W | 21-45 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |
Away History
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |