Head to Head
| Malta Premier League | 2022/04/09 13:00 | Santa Lucia FC v Sirens | D | 2-2 |
| Malta FA Trophy | 2022/02/10 18:00 | Santa Lucia FC v Sirens | W | 4-1 |
| Malta Premier League | 2022/01/23 15:00 | Sirens v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2021/09/18 15:00 | Santa Lucia FC v Sirens | L | 1-3 |
| Malta Premier League | 2020/12/08 13:00 | Sirens v Santa Lucia FC | W | 0-2 |
| Malta Premier League | 2020/02/15 13:00 | Santa Lucia FC v Sirens | L | 0-2 |
| Malta Premier League | 2019/09/28 15:15 | Sirens v Santa Lucia FC | L | 3-1 |
| Europe Friendlies | 2019/07/29 16:01 | Sirens v Santa Lucia FC | D | 1-1 |
Home History
| Malta Premier League | 2022/09/11 18:45 | Santa Lucia FC v Birkirkara | L | 0-4 |
| Malta Premier League | 2022/09/03 16:30 | Zebbug Rangers FC v Santa Lucia FC | L | 2-0 |
| Malta Premier League | 2022/08/28 16:30 | Santa Lucia FC v Balzan FC | L | 0-2 |
| Malta Premier League | 2022/08/20 16:30 | Gzira United v Santa Lucia FC | L | 3-1 |
| Malta FA Trophy | 2022/05/10 17:30 | Santa Lucia FC v Valletta | L | 0-1 |
| Malta Premier League | 2022/05/06 17:00 | Valletta v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2022/05/01 14:00 | Santa Lucia FC v Sliema Wanderers | L | 1-2 |
| Malta Premier League | 2022/04/24 14:00 | Mosta FC v Santa Lucia FC | D | 1-1 |
Away History
| Malta Premier League | 2022/09/10 18:45 | Sirens v Hamrun Spartans | L | 0-2 |
| Malta Premier League | 2022/09/03 18:45 | Valletta v Sirens | D | 0-0 |
| Malta Premier League | 2022/08/27 16:30 | Sirens v Floriana | D | 2-2 |
| Malta Premier League | 2022/08/19 16:30 | Birkirkara v Sirens | L | 2-0 |
| Europe Friendlies | 2022/07/23 16:30 | Sirens v Valletta | L | 0-2 |
| Malta Premier League | 2022/05/05 17:00 | Mosta FC v Sirens | W | 2-3 |
| Malta Premier League | 2022/04/30 16:15 | Sirens v Balzan FC | L | 2-3 |
| Malta Premier League | 2022/04/23 16:15 | Sliema Wanderers v Sirens | W | 0-5 |