Home History
| Prem Rugby | 2022/10/16 14:00 | Harlequins v Leicester | L | 19-27 |
| Premier Rugby Cup | 2022/10/11 18:45 | Northampton v Harlequins | L | 49-29 |
| Prem Rugby | 2022/10/02 14:00 | Harlequins v Northampton | W | 35-29 |
| Premier Rugby Cup | 2022/09/28 18:30 | Harlequins v Saracens | W | 40-31 |
| Prem Rugby | 2022/09/25 14:00 | Exeter Chiefs v Harlequins | L | 43-42 |
| Premier Rugby Cup | 2022/09/21 18:45 | Harlequins v London Irish | L | 26-30 |
| Prem Rugby | 2022/09/17 14:00 | Harlequins v Saracens | L | 27-30 |
| Prem Rugby | 2022/09/10 14:00 | Newcastle Red Bulls v Harlequins | W | 31-40 |
Away History
| United Rugby Championship | 2022/10/15 14:05 | Sharks v Glasgow Warriors | W | 40-12 |
| United Rugby Championship | 2022/10/08 16:05 | Leinster v Sharks | L | 54-34 |
| United Rugby Championship | 2022/10/01 18:35 | Newport Gwent Dragons v Sharks | W | 19-20 |
| United Rugby Championship | 2022/09/23 16:30 | Zebre Parma v Sharks | W | 37-42 |
| Currie Cup Premier Division | 2022/06/10 14:00 | Western Province v Sharks | L | 28-21 |
| Currie Cup Premier Division | 2022/06/04 15:00 | Sharks v Golden Lions | L | 32-38 |
| United Rugby Championship | 2022/06/04 11:45 | Blue Bulls v Sharks | L | 30-27 |
| United Rugby Championship | 2022/05/20 18:35 | Ulster v Sharks | L | 24-21 |