Stadium: Moretz Stadium Round: 1
| NCAAF | 2021/11/20 18:00 | Bowie State Bulldogs v Lenoir Rhyne Bears | L | 31-10 |
| NCAAF | 2021/11/13 18:00 | Lenoir Rhyne Bears v Catawba College | W | 56-3 |
| NCAAF | 2021/11/06 20:00 | Barton Bulldogs v Lenoir Rhyne Bears | W | 20-56 |
| NCAAF | 2021/10/30 22:00 | Wingate Bulldogs v Lenoir Rhyne Bears | W | 6-31 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | W | 45-3 |
| NCAAF | 2021/10/16 17:00 | Carson–Newman Eagles v Lenoir Rhyne Bears | W | 0-59 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | W | 38-31 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 35-28 |
| NCAAF | 2021/11/06 18:00 | Virginia Union Panthers v Virginia State Trojans | L | 20-13 |
| NCAAF | 2021/10/30 18:00 | Virginia State Trojans v Chowan Hawks | L | 30-38 |
| NCAAF | 2021/10/23 18:00 | Virginia State Trojans v Lincoln University | W | 23-3 |
| NCAAF | 2021/10/16 17:00 | Bowie State Bulldogs v Virginia State Trojans | L | 51-44 |
| NCAAF | 2021/10/09 22:00 | Virginia State Trojans v Elizabeth City State Vikings | W | 35-7 |
| NCAAF | 2021/10/02 22:00 | Virginia State Trojans v St Augustines Falcons | W | 33-9 |
| NCAAF | 2021/09/25 23:00 | Fayetteville State Broncos v Virginia State Trojans | L | 28-14 |
| NCAAF | 2021/09/11 17:00 | Ohio Dominican Panthers v Virginia State Trojans | L | 10-7 |