Stadium: Memorial Stadium/Bob Cunningham Field Round: 1
| NCAAF | 2021/11/13 18:00 | Minnesota State University Moorhead Dragons v Wayne State Wildcats | W | 21-24 |
| NCAAF | 2021/11/06 18:00 | Wayne State Wildcats v Sioux Falls Cougars | L | 17-38 |
| NCAAF | 2021/10/30 17:00 | Upper Iowa v Wayne State Wildcats | L | 42-41 |
| NCAAF | 2021/10/23 22:00 | Southwest Minnesota State Mustangs v Wayne State Wildcats | W | 16-38 |
| NCAAF | 2021/10/16 18:00 | Wayne State Wildcats v Augustana Vikings | L | 24-32 |
| NCAAF | 2021/10/09 18:00 | Minnesota State Mankato Mavericks v Wayne State Wildcats | W | 24-35 |
| NCAAF | 2021/10/02 18:00 | Wayne State Wildcats v Winona State Warriors | W | 38-21 |
| NCAAF | 2021/09/25 23:00 | Minnesota Duluth Bulldogs v Wayne State Wildcats | W | 28-31 |
| NCAAF | 2021/11/13 19:00 | Minnesota Duluth Bulldogs v Northern State Wolves | L | 49-35 |
| NCAAF | 2021/11/06 18:00 | Northern State Wolves v Bemidji State Beavers | L | 34-36 |
| NCAAF | 2021/10/30 17:00 | Minnesota State University Moorhead Dragons v Northern State Wolves | W | 27-33 |
| NCAAF | 2021/10/23 17:00 | Concordia University Golden Bears v Northern State Wolves | W | 17-38 |
| NCAAF | 2021/10/16 23:00 | Northern State Wolves v Minot State Beavers | W | 36-35 |
| NCAAF | 2021/10/09 19:00 | Winona State Warriors v Northern State Wolves | W | 49-52 |
| NCAAF | 2021/10/02 19:00 | Northern State Wolves v University of Mary Marauders | L | 42-49 |
| NCAAF | 2021/09/25 23:00 | Northern State Wolves v Sioux Falls Cougars | W | 41-10 |