Head to Head
| Ghana Premier League | 2022/04/02 15:00 | Hearts of Oak v Medeama SC | L | 1-0 |
| Ghana Premier League | 2022/01/12 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
| Ghana FA Cup | 2021/08/01 18:00 | Hearts of Oak v Medeama SC | L | 3-0 |
| Ghana Premier League | 2021/06/13 18:00 | Hearts of Oak v Medeama SC | L | 2-0 |
| Ghana Premier League | 2021/02/04 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
| Ghana Premier League | 2020/01/05 15:00 | Medeama SC v Hearts of Oak | W | 3-0 |
| Ghana Premier League | 2018/06/03 15:00 | Hearts of Oak v Medeama SC | D | 1-1 |
| Ghana Premier League | 2017/10/15 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
Home History
| Ghana Premier League | 2022/09/11 15:00 | Legon Cities FC v Medeama SC | W | 0-1 |
| Ghana Premier League | 2022/06/19 15:00 | Dreams v Medeama SC | L | 2-0 |
| Ghana Premier League | 2022/06/12 15:00 | Medeama SC v Accra Lions FC | W | 2-1 |
| Ghana Premier League | 2022/06/05 15:00 | Elmina Sharks v Medeama SC | W | 1-3 |
| Ghana Premier League | 2022/05/29 15:00 | Medeama SC v Asante Kotoko | L | 0-2 |
| Ghana Premier League | 2022/05/21 15:00 | Great Olympics v Medeama SC | W | 1-2 |
| Ghana Premier League | 2022/05/18 15:00 | Berekum Chelsea v Medeama SC | D | 0-0 |
| Ghana Premier League | 2022/05/08 15:00 | Medeama SC v Ashanti Gold | W | 2-0 |
Away History
| Ghana Premier League | 2022/09/11 15:00 | Aduana Stars v Hearts of Oak | L | 1-0 |
| Ghana FA Cup | 2022/06/26 17:00 | Hearts of Oak v Bechem FC | W | 2-1 |
| Ghana Premier League | 2022/06/19 15:00 | Hearts of Oak v Real Tamale United | L | 1-4 |
| Ghana Premier League | 2022/06/12 15:00 | Great Olympics v Hearts of Oak | L | 3-0 |
| Ghana Premier League | 2022/06/08 15:00 | Eleven Wonders v Hearts of Oak | L | 2-1 |
| Ghana Premier League | 2022/06/05 18:00 | King Faisal v Hearts of Oak | L | 1-0 |
| Ghana Premier League | 2022/05/30 15:00 | Hearts of Oak v Karela United FC | D | 1-1 |
| Ghana Premier League | 2022/05/18 15:00 | Hearts of Oak v Bibiani Gold Stars | W | 1-0 |