Stadium: Perkins Stadium Round: 1
| NCAAF | 2021/11/20 19:00 | Western New Mexico Mustangs v N. Mexico H. Cowboys | W | 28-31 |
| NCAAF | 2021/11/06 18:00 | N. Mexico H. Cowboys v South Dakota Mines Hardrockers | L | 17-40 |
| NCAAF | 2021/10/30 19:00 | N. Mexico H. Cowboys v Adams State Grizzlies | W | 58-28 |
| NCAAF | 2021/10/23 19:00 | Black Hills State v N. Mexico H. Cowboys | W | 10-24 |
| NCAAF | 2021/10/16 19:00 | N. Mexico H. Cowboys v Colorado State Pueblo Thunderwolves | W | 28-21 |
| NCAAF | 2021/10/09 19:00 | Western State Colorado Mountaineers v N. Mexico H. Cowboys | L | 45-38 |
| NCAAF | 2021/10/02 18:00 | N. Mexico H. Cowboys v Chadron State Eagles | L | 16-46 |
| NCAAF | 2021/09/25 23:00 | Tarleton State v N. Mexico H. Cowboys | L | 40-21 |
| NCAAF | 2021/11/13 22:00 | East Texas A&M v Eastern New Mexico University Greyhounds | L | 30-10 |
| NCAAF | 2021/11/06 17:00 | North American Stallions v Eastern New Mexico University Greyhounds | W | 21-70 |
| NCAAF | 2021/10/31 00:00 | Eastern New Mexico University Greyhounds v Angelo State Univeristy Rams | L | 7-59 |
| NCAAF | 2021/10/23 23:00 | Texas-Permian Basin Falcons v Eastern New Mexico University Greyhounds | L | 44-21 |
| NCAAF | 2021/10/17 00:00 | Eastern New Mexico University Greyhounds v West Texas AM Buffaloes | L | 24-44 |
| NCAAF | 2021/10/10 00:00 | Western New Mexico Mustangs v Eastern New Mexico University Greyhounds | W | 47-50 |
| NCAAF | 2021/10/03 00:00 | Eastern New Mexico University Greyhounds v Lincoln Oaklanders | W | 52-6 |
| NCAAF | 2021/09/26 00:00 | Midwestern State University Mustangs v Eastern New Mexico University Greyhounds | L | 31-24 |