Stadium: Albert J. Sloan–Alumni Stadium Round: 1
| NCAAF | 2021/11/06 18:00 | Miles Golden Bears v Tuskegee | W | 52-23 |
| NCAAF | 2021/10/30 22:00 | Edward Waters Tigers v Miles Golden Bears | W | 9-16 |
| NCAAF | 2021/10/23 17:00 | Kentucky Thorobreds v Miles Golden Bears | W | 21-28 |
| NCAAF | 2021/10/16 19:00 | Lane College Dragons v Miles Golden Bears | W | 31-34 |
| NCAAF | 2021/10/09 21:00 | Miles Golden Bears v Benedict College | L | 21-24 |
| NCAAF | 2021/10/02 23:00 | Miles Golden Bears v Albany State Golden Rams | L | 3-31 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | W | 55-4 |
| NCAAF | 2021/09/18 18:00 | Morehouse v Miles Golden Bears | W | 14-37 |
| NCAAF | 2022/09/01 23:00 | Valdosta State v Keiser University Seahawks | W | 36-21 |
| NCAAF | 2021/12/19 02:00 | Valdosta State v Ferris State | L | 17-58 |
| NCAAF | 2021/12/11 17:00 | Valdosta State v Colorado School of Mines | W | 34-31 |
| NCAAF | 2021/12/04 18:00 | Valdosta State v Bowie State Bulldogs | W | 41-17 |
| NCAAF | 2021/11/27 18:00 | Valdosta State v West Georgia | W | 66-35 |
| NCAAF | 2021/11/13 22:00 | West Florida v Valdosta State | L | 61-42 |
| NCAAF | 2021/11/06 19:00 | Valdosta State v North Greenville Crusaders | W | 31-21 |
| NCAAF | 2021/10/30 23:00 | Valdosta State v West Georgia | W | 36-34 |