Stadium: Williams Stadium Round: 1
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | W | 33-37 |
| NCAAF | 2019/11/16 18:30 | Otterbein Cardinals v Wilmington Quakers | W | 27-28 |
| NCAAF | 2018/11/10 18:30 | Wilmington Quakers v Otterbein Cardinals | L | 24-34 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | W | 33-37 |
| NCAAF | 2021/11/06 19:00 | Wilmington Quakers v Capital Crusaders | W | 24-21 |
| NCAAF | 2021/10/30 19:00 | John Carroll Blue Streaks v Wilmington Quakers | L | 50-7 |
| NCAAF | 2021/10/23 19:00 | Baldwin Wallace Yellow Jackets v Wilmington Quakers | L | 41-7 |
| NCAAF | 2021/10/16 19:00 | Wilmington Quakers v Marietta Pioneers | L | 7-35 |
| NCAAF | 2021/10/09 19:00 | Wilmington Quakers v Mount Union | L | 0-63 |
| NCAAF | 2021/09/25 17:30 | Muskingum Muskies v Wilmington Quakers | L | 62-14 |
| NCAAF | 2021/09/18 19:00 | Wilmington Quakers v Ohio Northern Polar Bears | L | 27-62 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | L | 33-37 |
| NCAAF | 2021/11/06 17:30 | Marietta Pioneers v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/10/30 17:30 | Capital Crusaders v Otterbein Cardinals | W | 33-38 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | L | 14-31 |
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 |
| NCAAF | 2021/10/02 17:30 | Mount Union v Otterbein Cardinals | L | 55-0 |
| NCAAF | 2021/09/25 17:30 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/09/18 18:00 | Otterbein Cardinals v John Carroll Blue Streaks | L | 17-41 |