Stadium: Francis G. Welch Stadium Round: 1
| NCAAF | 2021/09/18 23:00 | Missouri Western Griffons v Emporia State | L | 38-37 |
| NCAAF | 2019/10/26 18:00 | Missouri Western Griffons v Emporia State | L | 28-0 |
| NCAAF | 2018/10/20 19:00 | Emporia State v Missouri Western Griffons | L | 28-42 |
| NCAAF | 2021/11/13 19:30 | NW Missouri State v Emporia State | L | 35-7 |
| NCAAF | 2021/11/06 18:00 | Emporia State v Blue Tigers | W | 56-21 |
| NCAAF | 2021/10/30 18:00 | Fort Hays State University Tigers v Emporia State | W | 12-15 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | W | 24-21 |
| NCAAF | 2021/10/16 18:00 | Emporia State v Nebraska Kearney | L | 35-42 |
| NCAAF | 2021/10/09 18:00 | Central Missouri Mules v Emporia State | L | 45-38 |
| NCAAF | 2021/10/02 18:00 | Emporia State v Washburn Ichabods Football | W | 35-30 |
| NCAAF | 2021/09/26 00:00 | Pittsburgh State Gorillas v Emporia State | L | 30-28 |
| NCAAF | 2021/11/13 17:00 | Blue Tigers v Missouri Western Griffons | W | 12-41 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | W | 59-28 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | W | 28-45 |
| NCAAF | 2021/10/23 21:00 | Missouri Western Griffons v Pittsburgh State Gorillas | L | 14-34 |
| NCAAF | 2021/10/16 21:00 | Missouri Western Griffons v Northeastern State Riverhawks | W | 57-24 |
| NCAAF | 2021/10/09 19:00 | Nebraska Kearney v Missouri Western Griffons | L | 35-14 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | L | 7-30 |
| NCAAF | 2021/09/25 18:00 | Washburn Ichabods Football v Missouri Western Griffons | L | 47-41 |