Stadium: First Security Stadium Round: 1
| NCAAF | 2021/09/18 23:00 | Southern Arkansas Muleriders v Harding | W | 6-37 |
| NCAAF | 2019/09/21 23:00 | Southern Arkansas Muleriders v Harding | W | 0-31 |
| NCAAF | 2021/11/27 19:00 | Harding v NW Missouri State | L | 9-28 |
| NCAAF | 2021/11/20 19:00 | Harding v Washburn Ichabods Football | W | 30-14 |
| NCAAF | 2021/11/13 20:00 | Arkansas Tech Wonder Boys v Harding | W | 0-31 |
| NCAAF | 2021/11/06 19:00 | Southwestern Oklahoma State Bulldogs v Harding | W | 7-55 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding | W | 14-73 |
| NCAAF | 2021/10/23 20:00 | Harding v Arkansas Monticello Boll Weevils | W | 64-7 |
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding | W | 21-46 |
| NCAAF | 2021/10/09 19:00 | Harding v Southern Nazarene | W | 49-10 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |
| NCAAF | 2021/09/25 23:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 56-49 |