Stadium: Callaway Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Lagrange Panthers v Huntingdon Hawks | L | 9-55 |
| NCAAF | 2021/11/06 17:00 | Averett Cougars v Lagrange Panthers | L | 31-22 |
| NCAAF | 2021/10/30 17:00 | Lagrange Panthers v Greensboro | W | 29-14 |
| NCAAF | 2021/10/23 18:00 | Maryville Scots v Lagrange Panthers | L | 52-16 |
| NCAAF | 2021/10/16 20:00 | Lagrange Panthers v Brevard Tornados | L | 10-20 |
| NCAAF | 2021/10/09 17:00 | Methodist Monarchs v Lagrange Panthers | L | 34-17 |
| NCAAF | 2021/09/25 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 21-26 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | W | 34-38 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | L | 41-23 |
| NCAAF | 2021/11/06 17:00 | Washington And Lee Generals v Ferrum Panthers | L | 28-24 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | W | 57-35 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | W | 24-23 |
| NCAAF | 2021/10/09 18:00 | Bridgewater Eagles v Ferrum Panthers | W | 10-14 |
| NCAAF | 2021/10/02 17:00 | Ferrum Panthers v Randolph Macon Yellow Jackets | L | 21-44 |
| NCAAF | 2021/09/25 17:00 | Ferrum Panthers v The Apprentice School Builders | W | 30-28 |