Stadium: Lloyd L. Thornton Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Maryville Scots v Greensboro | W | 49-14 |
| NCAAF | 2021/11/06 18:00 | Huntingdon Hawks v Maryville Scots | L | 52-33 |
| NCAAF | 2021/10/23 18:00 | Maryville Scots v Lagrange Panthers | W | 52-16 |
| NCAAF | 2021/10/16 16:00 | Nc Wesleyan Battling Bishops v Maryville Scots | W | 26-31 |
| NCAAF | 2021/10/09 18:00 | Brevard Tornados v Maryville Scots | L | 31-0 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | W | 38-17 |
| NCAAF | 2021/09/25 22:00 | Averett Cougars v Maryville Scots | L | 47-10 |
| NCAAF | 2021/09/18 17:00 | Maryville Scots v Methodist Monarchs | L | 21-38 |
| NCAAF | 2021/11/13 18:00 | Shenandoah Hornets v Washington And Lee Generals | W | 14-6 |
| NCAAF | 2021/11/06 17:00 | Shenandoah Hornets v The Apprentice School Builders | W | 35-16 |
| NCAAF | 2021/10/30 17:00 | Randolph Macon Yellow Jackets v Shenandoah Hornets | L | 45-14 |
| NCAAF | 2021/10/23 17:00 | Shenandoah Hornets v Emory And Henry Wasps | W | 9-7 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | L | 24-23 |
| NCAAF | 2021/10/09 16:00 | Guilford Quakers v Shenandoah Hornets | W | 25-52 |
| NCAAF | 2021/10/02 23:00 | Shenandoah Hornets v Bridgewater Eagles | W | 34-27 |
| NCAAF | 2021/09/18 17:00 | Hampden Sydney Tigers v Shenandoah Hornets | L | 28-7 |