Stadium: Plaster Stadium Round: 1
| NCAAF | 2021/11/13 19:00 | Southwest Baptist University Bearcats v Missouri S&t Miners | L | 41-42 |
| NCAAF | 2021/11/06 18:00 | Quincy v Southwest Baptist University Bearcats | W | 31-47 |
| NCAAF | 2021/10/30 18:00 | Southwest Baptist University Bearcats v McKendree | L | 42-45 |
| NCAAF | 2021/10/23 18:00 | Lindenwood v Southwest Baptist University Bearcats | L | 48-24 |
| NCAAF | 2021/10/16 18:00 | Southwest Baptist University Bearcats v Truman Bulldogs | W | 27-21 |
| NCAAF | 2021/10/09 20:00 | William Jewell College Cardinals v Southwest Baptist University Bearcats | W | 10-55 |
| NCAAF | 2021/10/02 18:00 | Southwest Baptist University Bearcats v Indianapolis Greyhounds | L | 10-77 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | W | 20-28 |
| NCAAF | 2021/11/13 18:00 | Lake Erie v Walsh U. Cavaliers | L | 7-24 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |