Stadium: Hardee-McGee Field at Harris Stadium Round: 1
| NCAAF | 2021/10/30 18:00 | Millsaps Majors v Sewanee Tigers | L | 42-32 |
| NCAAF | 2019/11/02 18:30 | Sewanee Tigers v Millsaps Majors | L | 25-49 |
| NCAAF | 2018/09/22 18:00 | Sewanee Tigers v Millsaps Majors | L | 14-21 |
| NCAAF | 2021/11/13 19:00 | Sewanee Tigers v Hendrix Warriors | L | 10-56 |
| NCAAF | 2021/11/06 18:30 | Sewanee Tigers v Centre Colonels | L | 20-30 |
| NCAAF | 2021/10/30 18:00 | Millsaps Majors v Sewanee Tigers | L | 42-32 |
| NCAAF | 2021/10/23 17:00 | Sewanee Tigers v Trinity Tigers | L | 7-66 |
| NCAAF | 2021/10/16 19:00 | Berry Vikings v Sewanee Tigers | L | 59-0 |
| NCAAF | 2021/10/09 18:00 | Sewanee Tigers v Rhodes Lynx | L | 13-55 |
| NCAAF | 2021/10/02 23:00 | Birmingham Southern Panthers v Sewanee Tigers | L | 49-0 |
| NCAAF | 2021/09/18 18:00 | Sewanee Tigers v Westminster Blue Jays | L | 29-30 |
| NCAAF | 2021/11/13 19:00 | Millsaps Majors v Birmingham Southern Panthers | L | 7-49 |
| NCAAF | 2021/11/06 23:00 | Hendrix Warriors v Millsaps Majors | L | 34-7 |
| NCAAF | 2021/10/30 18:00 | Millsaps Majors v Sewanee Tigers | W | 42-32 |
| NCAAF | 2021/10/23 17:00 | Millsaps Majors v Centre Colonels | L | 34-66 |
| NCAAF | 2021/10/16 18:00 | Trinity Tigers v Millsaps Majors | L | 46-0 |
| NCAAF | 2021/10/09 18:00 | Millsaps Majors v Berry Vikings | L | 21-49 |
| NCAAF | 2021/10/02 19:00 | Rhodes Lynx v Millsaps Majors | W | 21-42 |
| NCAAF | 2021/09/25 17:00 | Millsaps Majors v Olivet Comets | L | 27-44 |