Stadium: Hollett Little Giant Stadium Round: 1
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | W | 38-39 |
| NCAAF | 2019/09/28 18:00 | Wabash Little Giants v Denison Big Red | W | 34-20 |
| NCAAF | 2018/10/06 19:00 | Denison Big Red v Wabash Little Giants | L | 34-10 |
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | W | 42-35 |
| NCAAF | 2021/11/06 17:00 | Wabash Little Giants v Wittenberg Tigers | L | 14-35 |
| NCAAF | 2021/10/30 17:00 | Kenyon Lords v Wabash Little Giants | W | 34-59 |
| NCAAF | 2021/10/23 17:00 | Ohio Wesleyan Battling Bishops v Wabash Little Giants | L | 35-28 |
| NCAAF | 2021/10/16 17:00 | Wabash Little Giants v Wooster Scots | L | 41-44 |
| NCAAF | 2021/10/09 18:00 | Wabash Little Giants v Oberlin Yeomen | W | 49-20 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | W | 38-39 |
| NCAAF | 2021/09/18 18:00 | Wabash Little Giants v Allegheny Gators | W | 36-28 |
| NCAAF | 2021/11/13 18:00 | Denison Big Red v Ohio Wesleyan Battling Bishops | L | 25-35 |
| NCAAF | 2021/11/06 17:00 | Hiram Terriers v Denison Big Red | W | 6-59 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | L | 27-10 |
| NCAAF | 2021/10/23 19:00 | Denison Big Red v Wooster Scots | W | 52-28 |
| NCAAF | 2021/10/16 17:00 | Kenyon Lords v Denison Big Red | W | 7-45 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | L | 38-39 |
| NCAAF | 2021/09/25 23:00 | Denison Big Red v Wittenberg Tigers | W | 21-16 |
| NCAAF | 2021/09/18 17:00 | Oberlin Yeomen v Denison Big Red | W | 12-59 |