Stadium: Tucci Stadium Round: 1
| NCAAF | 2021/10/16 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | W | 14-0 |
| NCAAF | 2019/11/02 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | W | 40-12 |
| NCAAF | 2018/10/27 23:00 | Millikin Big Blue v Illinois Wesleyan Titans | W | 32-49 |
| NCAAF | 2021/11/13 19:00 | Illinois Wesleyan Titans v Augustana Augie | L | 14-38 |
| NCAAF | 2021/11/06 18:00 | Wheaton Thunder v Illinois Wesleyan Titans | L | 72-7 |
| NCAAF | 2021/10/30 18:00 | Illinois Wesleyan Titans v North Park Vikings | W | 56-6 |
| NCAAF | 2021/10/23 23:00 | North Central Illinois v Illinois Wesleyan Titans | L | 55-7 |
| NCAAF | 2021/10/16 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | W | 14-0 |
| NCAAF | 2021/10/09 18:00 | Washington Bears v Illinois Wesleyan Titans | L | 38-22 |
| NCAAF | 2021/10/02 18:00 | Illinois Wesleyan Titans v Elmhurst Bluejays | W | 52-3 |
| NCAAF | 2021/09/25 18:00 | Carthage Red Men v Illinois Wesleyan Titans | L | 62-35 |
| NCAAF | 2021/11/13 19:00 | Millikin Big Blue v Wheaton Thunder | L | 7-49 |
| NCAAF | 2021/11/06 18:00 | North Park Vikings v Millikin Big Blue | W | 0-21 |
| NCAAF | 2021/10/30 23:00 | Millikin Big Blue v North Central Illinois | L | 27-54 |
| NCAAF | 2021/10/23 23:00 | Millikin Big Blue v Washington Bears | L | 13-55 |
| NCAAF | 2021/10/16 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | L | 14-0 |
| NCAAF | 2021/10/09 18:00 | Elmhurst Bluejays v Millikin Big Blue | L | 28-7 |
| NCAAF | 2021/10/02 18:00 | Millikin Big Blue v Carthage Red Men | L | 42-63 |
| NCAAF | 2021/09/25 23:00 | Millikin Big Blue v Carroll Pioneers | W | 32-25 |