Stadium: CAU Panther Stadium Round: 1
| NCAAF | 2021/10/02 18:00 | Tuskegee v Clark Atlanta | L | 21-0 |
| NCAAF | 2018/09/15 23:00 | Clark Atlanta v Tuskegee | L | 17-24 |
| NCAAF | 2021/11/06 18:00 | Clark Atlanta v Morehouse | L | 26-35 |
| NCAAF | 2021/10/30 18:00 | Clark Atlanta v Benedict College | L | 21-24 |
| NCAAF | 2021/10/23 18:00 | Fort Valley State v Clark Atlanta | L | 40-7 |
| NCAAF | 2021/10/16 19:00 | Savannah State v Clark Atlanta | L | 49-14 |
| NCAAF | 2021/10/09 18:00 | Clark Atlanta v Allen Yellow Jackets | W | 21-12 |
| NCAAF | 2021/10/02 18:00 | Tuskegee v Clark Atlanta | L | 21-0 |
| NCAAF | 2021/09/25 23:00 | Albany State Golden Rams v Clark Atlanta | L | 49-0 |
| NCAAF | 2021/09/18 16:00 | Clark Atlanta v Shorter | L | 17-38 |
| NCAAF | 2021/11/25 20:00 | Tuskegee v Alabama State | L | 9-43 |
| NCAAF | 2021/11/06 18:00 | Miles Golden Bears v Tuskegee | L | 52-23 |
| NCAAF | 2021/10/30 18:00 | Tuskegee v Kentucky Thorobreds | L | 35-42 |
| NCAAF | 2021/10/23 18:00 | Tuskegee v Lane College Dragons | L | 17-21 |
| NCAAF | 2021/10/16 17:00 | Central State v Tuskegee | W | 0-29 |
| NCAAF | 2021/10/10 00:00 | Morehouse v Tuskegee | L | 31-15 |
| NCAAF | 2021/10/02 18:00 | Tuskegee v Clark Atlanta | W | 21-0 |
| NCAAF | 2021/09/25 21:00 | Tuskegee v Alabama A&M | L | 35-45 |