Stadium: W. B. Adams Stadium Round: 1
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2019/11/09 18:00 | Hampden Sydney Tigers v Ferrum Panthers | W | 14-31 |
| NCAAF | 2018/10/27 18:00 | Ferrum Panthers v Hampden Sydney Tigers | W | 32-19 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | L | 41-23 |
| NCAAF | 2021/11/06 17:00 | Washington And Lee Generals v Ferrum Panthers | L | 28-24 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | W | 57-35 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | W | 24-23 |
| NCAAF | 2021/10/09 18:00 | Bridgewater Eagles v Ferrum Panthers | W | 10-14 |
| NCAAF | 2021/10/02 17:00 | Ferrum Panthers v Randolph Macon Yellow Jackets | L | 21-44 |
| NCAAF | 2021/09/25 17:00 | Ferrum Panthers v The Apprentice School Builders | W | 30-28 |
| NCAAF | 2021/11/13 18:00 | Randolph Macon Yellow Jackets v Hampden Sydney Tigers | L | 37-14 |
| NCAAF | 2021/11/06 17:00 | Hampden Sydney Tigers v Bridgewater Eagles | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | The Apprentice School Builders v Hampden Sydney Tigers | W | 21-38 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | W | 42-28 |
| NCAAF | 2021/10/16 17:00 | Emory And Henry Wasps v Hampden Sydney Tigers | L | 37-13 |
| NCAAF | 2021/10/02 17:00 | Hampden Sydney Tigers v Washington And Lee Generals | L | 30-32 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 27-28 |
| NCAAF | 2021/09/18 17:00 | Hampden Sydney Tigers v Shenandoah Hornets | W | 28-7 |