Stadium: Armfield Athletic Center Round: 1
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | L | 57-35 |
| NCAAF | 2019/10/12 17:00 | Ferrum Panthers v Guilford Quakers | L | 45-23 |
| NCAAF | 2018/10/12 23:00 | Guilford Quakers v Ferrum Panthers | W | 28-27 |
| NCAAF | 2021/11/13 19:00 | Bridgewater Eagles v Guilford Quakers | L | 43-0 |
| NCAAF | 2021/11/06 17:00 | Guilford Quakers v Emory And Henry Wasps | L | 13-66 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | L | 57-35 |
| NCAAF | 2021/10/16 17:00 | Guilford Quakers v Randolph Macon Yellow Jackets | L | 0-58 |
| NCAAF | 2021/10/09 16:00 | Guilford Quakers v Shenandoah Hornets | L | 25-52 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | L | 27-28 |
| NCAAF | 2021/09/18 17:00 | Washington And Lee Generals v Guilford Quakers | L | 52-0 |
| NCAAF | 2021/09/04 23:00 | Guilford Quakers v Greensboro | W | 21-7 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | L | 41-23 |
| NCAAF | 2021/11/06 17:00 | Washington And Lee Generals v Ferrum Panthers | L | 28-24 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | W | 57-35 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | W | 24-23 |
| NCAAF | 2021/10/09 18:00 | Bridgewater Eagles v Ferrum Panthers | W | 10-14 |
| NCAAF | 2021/10/02 17:00 | Ferrum Panthers v Randolph Macon Yellow Jackets | L | 21-44 |
| NCAAF | 2021/09/25 17:00 | Ferrum Panthers v The Apprentice School Builders | W | 30-28 |