Stadium: James Work Memorial Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-30 |
| NCAAF | 2019/10/19 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-42 |
| NCAAF | 2018/09/15 17:00 | Delaware Valley Aggies v Wilkes Colonels | W | 21-10 |
| NCAAF | 2021/11/27 17:00 | Delaware Valley Aggies v Muhlenberg Mules | L | 0-14 |
| NCAAF | 2021/11/20 17:00 | Delaware Valley Aggies v Anna Maria Amcats | W | 62-10 |
| NCAAF | 2021/11/13 17:00 | Delaware Valley Aggies v Widener Pride | W | 27-0 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-30 |
| NCAAF | 2021/10/30 17:00 | Delaware Valley Aggies v Lebanon Valley Flying Dutchmen | W | 31-3 |
| NCAAF | 2021/10/23 17:00 | Misericordia Cougars v Delaware Valley Aggies | W | 0-35 |
| NCAAF | 2021/10/16 16:00 | Fdu Florham Devils v Delaware Valley Aggies | W | 7-61 |
| NCAAF | 2021/10/09 17:00 | Delaware Valley Aggies v Kings Monarchs | W | 48-15 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 |
| NCAAF | 2021/10/30 17:00 | Lycoming Warriors v Wilkes Colonels | L | 30-27 |
| NCAAF | 2021/10/23 17:00 | Wilkes Colonels v Lebanon Valley Flying Dutchmen | W | 30-20 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | L | 30-13 |
| NCAAF | 2021/10/09 16:00 | Albright Lions v Wilkes Colonels | W | 28-31 |
| NCAAF | 2021/10/02 16:00 | Wilkes Colonels v Stevenson Mustangs | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Wilkes Colonels v Alvernia Golden Wolves | W | 23-0 |