Stadium: Bob Young Field Round: 1
| NCAAF | 2021/10/09 22:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | W | 7-35 |
| NCAAF | 2019/09/21 18:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | W | 7-51 |
| NCAAF | 2018/09/15 23:05 | Sioux Falls Cougars v Southwest Minnesota State Mustangs | W | 39-21 |
| NCAAF | 2021/11/13 19:00 | Sioux Falls Cougars v Upper Iowa | W | 42-21 |
| NCAAF | 2021/11/06 18:00 | Wayne State Wildcats v Sioux Falls Cougars | W | 17-38 |
| NCAAF | 2021/10/30 18:00 | Minnesota State Mankato Mavericks v Sioux Falls Cougars | W | 35-45 |
| NCAAF | 2021/10/23 18:00 | Sioux Falls Cougars v Winona State Warriors | L | 10-14 |
| NCAAF | 2021/10/16 18:00 | Sioux Falls Cougars v University of Mary Marauders | W | 34-14 |
| NCAAF | 2021/10/09 22:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | W | 7-35 |
| NCAAF | 2021/10/02 18:00 | Sioux Falls Cougars v Augustana Vikings | W | 28-26 |
| NCAAF | 2021/09/25 23:00 | Northern State Wolves v Sioux Falls Cougars | L | 41-10 |
| NCAAF | 2021/11/13 19:00 | Augustana Vikings v Southwest Minnesota State Mustangs | L | 55-0 |
| NCAAF | 2021/11/06 18:00 | Southwest Minnesota State Mustangs v Minnesota State Mankato Mavericks | L | 0-52 |
| NCAAF | 2021/10/30 18:00 | Bemidji State Beavers v Southwest Minnesota State Mustangs | L | 48-14 |
| NCAAF | 2021/10/23 22:00 | Southwest Minnesota State Mustangs v Wayne State Wildcats | L | 16-38 |
| NCAAF | 2021/10/16 18:00 | Winona State Warriors v Southwest Minnesota State Mustangs | L | 26-14 |
| NCAAF | 2021/10/09 22:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | L | 7-35 |
| NCAAF | 2021/10/02 20:00 | Upper Iowa v Southwest Minnesota State Mustangs | W | 14-20 |
| NCAAF | 2021/09/25 17:00 | Concordia University Golden Bears v Southwest Minnesota State Mustangs | W | 24-34 |