Stadium: J. Henry “Hank” Cameron Stadium Round: 1
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | W | 12-14 |
| NCAAF | 2019/11/02 16:00 | Nichols Bison v Husson Eagles | W | 7-31 |
| NCAAF | 2021/11/13 18:00 | Western New England Golden Bears v Husson Eagles | L | 35-10 |
| NCAAF | 2021/11/06 16:00 | Husson Eagles v Salve Regina Seahawks | W | 24-10 |
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | W | 12-14 |
| NCAAF | 2021/10/23 17:00 | University of New England Noreasters v Husson Eagles | W | 14-41 |
| NCAAF | 2021/10/16 17:00 | Husson Eagles v Endicott Gulls | L | 17-24 |
| NCAAF | 2021/10/09 17:00 | Husson Eagles v Curry Colonels | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Husson Eagles v Springfield Pride | W | 26-21 |
| NCAAF | 2021/09/17 22:00 | Husson Eagles v Dean Bulldogs | W | 42-14 |
| NCAAF | 2021/11/13 17:00 | Nichols Bison v Endicott Gulls | L | 3-37 |
| NCAAF | 2021/11/06 17:00 | Curry Colonels v Nichols Bison | L | 28-14 |
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | L | 12-14 |
| NCAAF | 2021/10/23 17:00 | Western New England Golden Bears v Nichols Bison | L | 49-0 |
| NCAAF | 2021/10/16 16:00 | Nichols Bison v Salve Regina Seahawks | L | 20-35 |
| NCAAF | 2021/10/02 17:00 | University of New England Noreasters v Nichols Bison | L | 28-19 |
| NCAAF | 2021/09/25 17:00 | Nichols Bison v Tcnj Lions | L | 0-31 |
| NCAAF | 2021/09/18 17:30 | Coast Guard Bears v Nichols Bison | L | 33-6 |