Stadium: Callaway Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Lagrange Panthers v Huntingdon Hawks | L | 9-55 |
| NCAAF | 2021/11/06 17:00 | Averett Cougars v Lagrange Panthers | L | 31-22 |
| NCAAF | 2021/10/30 17:00 | Lagrange Panthers v Greensboro | W | 29-14 |
| NCAAF | 2021/10/23 18:00 | Maryville Scots v Lagrange Panthers | L | 52-16 |
| NCAAF | 2021/10/16 20:00 | Lagrange Panthers v Brevard Tornados | L | 10-20 |
| NCAAF | 2021/10/09 17:00 | Methodist Monarchs v Lagrange Panthers | L | 34-17 |
| NCAAF | 2021/09/25 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 21-26 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | W | 34-38 |
| NCAAF | 2021/11/06 16:00 | Nc Wesleyan Battling Bishops v Southern Virginia Knights | L | 19-10 |
| NCAAF | 2021/10/30 17:00 | Southern Virginia Knights v Averett Cougars | L | 23-28 |
| NCAAF | 2021/10/23 17:00 | Brevard Tornados v Southern Virginia Knights | L | 7-3 |
| NCAAF | 2021/10/16 17:00 | Southern Virginia Knights v Greensboro | W | 31-14 |
| NCAAF | 2021/10/09 17:00 | Southern Virginia Knights v Huntingdon Hawks | L | 20-48 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | L | 38-17 |
| NCAAF | 2021/09/25 17:00 | Methodist Monarchs v Southern Virginia Knights | L | 37-14 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | L | 34-38 |