Stadium: Mount Sports Complex/Schueler Field & Track Round: 1
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2019/10/05 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | W | 59-6 |
| NCAAF | 2018/10/20 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 0-20 |
| NCAAF | 2021/11/13 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | L | 58-21 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | W | 23-6 |
| NCAAF | 2021/10/30 17:30 | Mount St. Joseph Lions v Anderson Ravens | W | 35-18 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | W | 28-0 |
| NCAAF | 2021/10/09 17:30 | Mount St. Joseph Lions v Franklin College Grizzlies | W | 28-14 |
| NCAAF | 2021/10/02 17:30 | Bluffton Beavers v Mount St. Joseph Lions | W | 27-45 |
| NCAAF | 2021/09/18 17:00 | Trine Thunder v Mount St. Joseph Lions | L | 31-30 |
| NCAAF | 2021/11/13 18:30 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 |
| NCAAF | 2021/11/06 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 |
| NCAAF | 2021/10/30 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 |
| NCAAF | 2021/09/25 16:00 | Defiance Yellow Jackets v Alfred State Pioneers | L | 28-35 |