Stadium: Sherman Field at Kearly Stadium Round: 1
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | W | 14-31 |
| NCAAF | 2019/10/26 17:30 | Otterbein Cardinals v Muskingum Muskies | L | 18-10 |
| NCAAF | 2018/10/20 18:00 | Muskingum Muskies v Otterbein Cardinals | W | 21-14 |
| NCAAF | 2021/11/13 18:30 | Capital Crusaders v Muskingum Muskies | W | 27-46 |
| NCAAF | 2021/11/06 17:30 | Mount Union v Muskingum Muskies | L | 73-7 |
| NCAAF | 2021/10/30 17:30 | Muskingum Muskies v Heidelberg Student Princes | L | 14-49 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | W | 14-31 |
| NCAAF | 2021/10/16 20:00 | Muskingum Muskies v Baldwin Wallace Yellow Jackets | L | 10-49 |
| NCAAF | 2021/10/02 17:30 | John Carroll Blue Streaks v Muskingum Muskies | L | 29-7 |
| NCAAF | 2021/09/25 17:30 | Muskingum Muskies v Wilmington Quakers | W | 62-14 |
| NCAAF | 2021/09/18 23:00 | Marietta Pioneers v Muskingum Muskies | L | 18-0 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | L | 33-37 |
| NCAAF | 2021/11/06 17:30 | Marietta Pioneers v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/10/30 17:30 | Capital Crusaders v Otterbein Cardinals | W | 33-38 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | L | 14-31 |
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 |
| NCAAF | 2021/10/02 17:30 | Mount Union v Otterbein Cardinals | L | 55-0 |
| NCAAF | 2021/09/25 17:30 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/09/18 18:00 | Otterbein Cardinals v John Carroll Blue Streaks | L | 17-41 |