Stadium: Audrey J. Walton Stadium Round: 1
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | L | 30-28 |
| NCAAF | 2019/10/05 19:00 | Missouri Southern Lions v Central Missouri Mules | W | 42-71 |
| NCAAF | 2018/09/29 18:00 | Central Missouri Mules v Missouri Southern Lions | W | 61-7 |
| NCAAF | 2022/09/24 18:00 | Nebraska Kearney v Central Missouri Mules | L | 38-6 |
| NCAAF | 2022/09/17 18:30 | NW Missouri State v Central Missouri Mules | L | 24-7 |
| NCAAF | 2022/09/09 00:00 | Central Missouri Mules v Washburn Ichabods Football | L | 32-40 |
| NCAAF | 2022/09/02 00:00 | Pittsburgh State Gorillas v Central Missouri Mules | L | 21-10 |
| NCAAF | 2021/11/13 19:00 | Central Missouri Mules v Central Oklahoma | W | 30-29 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | L | 59-28 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | W | 35-77 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | L | 17-21 |
| NCAAF | 2022/09/25 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | W | 40-21 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |
| NCAAF | 2021/11/13 19:00 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | L | 7-49 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |