Stadium: Carl W. Burt Memorial Stadium Round: 1
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2019/10/26 17:30 | Hanover v Manchester Spartans | L | 56-7 |
| NCAAF | 2018/10/20 17:30 | Manchester Spartans v Hanover | L | 14-48 |
| NCAAF | 2021/11/13 18:30 | Manchester Spartans v Anderson Ravens | W | 3-0 |
| NCAAF | 2021/11/06 17:30 | Bluffton Beavers v Manchester Spartans | L | 31-7 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |
| NCAAF | 2021/10/02 17:30 | Franklin College Grizzlies v Manchester Spartans | W | 24-27 |
| NCAAF | 2021/09/18 17:00 | Olivet Comets v Manchester Spartans | L | 59-7 |
| NCAAF | 2021/11/13 18:30 | Hanover v Franklin College Grizzlies | L | 16-27 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | L | 23-6 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | W | 33-0 |
| NCAAF | 2021/10/23 17:30 | Bluffton Beavers v Hanover | W | 10-41 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | W | 51-0 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | L | 31-21 |
| NCAAF | 2021/10/02 17:30 | Hanover v Anderson Ravens | W | 49-0 |
| NCAAF | 2021/09/18 17:00 | Albion Britons v Hanover | L | 24-14 |