Stadium: Meares Stadium Round: 1
| NCAAF | 2021/11/13 20:00 | Wingate Bulldogs v Mars Hill Lions | L | 26-19 |
| NCAAF | 2021/11/06 17:00 | Mars Hill Lions v Tusculum Pioneers | W | 20-7 |
| NCAAF | 2021/10/30 19:00 | Carson–Newman Eagles v Mars Hill Lions | W | 23-49 |
| NCAAF | 2021/10/23 17:00 | Mars Hill Lions v Catawba College | W | 31-14 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | W | 3-32 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | W | 40-32 |
| NCAAF | 2021/10/02 17:00 | Mars Hill Lions v Newberry Wolves | W | 28-22 |
| NCAAF | 2021/09/25 22:00 | Lenoir Rhyne Bears v Mars Hill Lions | L | 31-16 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | W | 41-23 |
| NCAAF | 2021/11/06 17:00 | Guilford Quakers v Emory And Henry Wasps | W | 13-66 |
| NCAAF | 2021/10/30 17:00 | Emory And Henry Wasps v Washington And Lee Generals | L | 28-30 |
| NCAAF | 2021/10/23 17:00 | Shenandoah Hornets v Emory And Henry Wasps | L | 9-7 |
| NCAAF | 2021/10/16 17:00 | Emory And Henry Wasps v Hampden Sydney Tigers | W | 37-13 |
| NCAAF | 2021/10/09 17:00 | Randolph Macon Yellow Jackets v Emory And Henry Wasps | L | 34-31 |
| NCAAF | 2021/09/25 17:00 | Emory And Henry Wasps v Bridgewater Eagles | W | 38-17 |
| NCAAF | 2021/09/18 17:00 | Emory And Henry Wasps v The Apprentice School Builders | W | 63-7 |