Stadium: Bob Shelton Stadium Round: 1
| NCAAF | 2021/09/11 23:00 | Sul Ross State Lobos v Hardin Simmons Cowboys | W | 0-27 |
| NCAAF | 2019/09/07 23:00 | Sul Ross State Lobos v Hardin Simmons Cowboys | W | 0-64 |
| NCAAF | 2018/10/13 18:00 | Hardin Simmons Cowboys v Sul Ross State Lobos | W | 48-27 |
| NCAAF | 2021/11/13 19:00 | Hardin Simmons Cowboys v Texas Lutheran Bulldogs | W | 65-0 |
| NCAAF | 2021/11/06 18:00 | Austin Kangaroos v Hardin Simmons Cowboys | W | 14-56 |
| NCAAF | 2021/10/30 18:00 | Howard Payne Yellow Jackets v Hardin Simmons Cowboys | W | 14-38 |
| NCAAF | 2021/10/23 18:00 | Hardin Simmons Cowboys v Southwestern Pirates | W | 69-7 |
| NCAAF | 2021/10/16 18:00 | East Texas Baptist Tigers v Hardin Simmons Cowboys | W | 0-34 |
| NCAAF | 2021/10/02 18:00 | Hardin Simmons Cowboys v Mcmurry Warhawks | W | 24-21 |
| NCAAF | 2021/09/25 23:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 34-28 |
| NCAAF | 2021/09/18 18:00 | Hardin Simmons Cowboys v Belhaven Blazers | W | 21-16 |
| NCAAF | 2021/11/13 19:00 | Southwestern Pirates v Sul Ross State Lobos | L | 49-15 |
| NCAAF | 2021/11/06 17:00 | Sul Ross State Lobos v East Texas Baptist Tigers | L | 28-31 |
| NCAAF | 2021/10/30 18:00 | Mcmurry Warhawks v Sul Ross State Lobos | W | 11-24 |
| NCAAF | 2021/10/23 18:00 | Sul Ross State Lobos v Mary Hardin Baylor | L | 14-72 |
| NCAAF | 2021/10/16 17:00 | Belhaven Blazers v Sul Ross State Lobos | L | 44-0 |
| NCAAF | 2021/10/09 21:00 | Sul Ross State Lobos v North American Stallions | L | 37-44 |
| NCAAF | 2021/10/02 20:30 | Howard Payne Yellow Jackets v Sul Ross State Lobos | L | 73-30 |
| NCAAF | 2021/09/25 23:00 | Sul Ross State Lobos v Texas Lutheran Bulldogs | W | 12-10 |